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It is commonly found in species of the Boraginaceae and the … Figure 1. Cell cycle deregulation in HNSCC. Normally, the cell cylcle is regulated by complexes of cyclins and cyclin-dependent kinases (CDKs). pRb binds to and inactivated E2F transcription factor, which induces in the expression of S phase genes.
CDK. cyclin dependent kinase. CDC28. Cdc2. Multiple CDKs: CDK1-6.